Cellulitis is an acute bacterial infection of the dermis and the subcutaneous tissue that most commonly affects the lower extremities, although it can affect other areas. It causes local signs of inflammation, such as warmth, erythema, pain, lymphangitis, and frequently systemic upset with fever and raised white blood cell count.

One of the following oral antibiotics

Cephalexin 500 mg 6-hourly

Amoxicillin-clavulanate 1,2 gr 8-hourly

Levofloxacin 750 mg 24-hourly


In patients needing intravenous administration

One of following antibiotics

Cefazolin 2 g-8 hourly

Amoxicillin-clavulanate 1,2-2,2 gr 8-hourly

Levofloxacin 750 mg 24-hourly

In patients at risk for CA-MRSA or who do not respond to first line therapy consider anti- MRSA antibiotics

Oral options:

Minocycline100 mg 12-hourly

Trimethoprim and sulfamethoxazole 160/800 mg 12-hourly

Doxycycline 100 mg 12-hourly

Clindamycin 300–600 mg 8-hourly (high resistance rate)

Linezolid 600 mg 12-hourly

Tedizolid 200 mg 24-hourly

Intravenous options:

Vancomycin 25–30 mg/kg loading dose then 15–20 mg/kg/dose 8-hourly

Teicoplanin LD 12 mg/kg 12-hourly for 3 doses, then 6 mg/kg 12-hourly

Tigecycline 100 mg as a single dose, then 50 mg 12-hourly

Linezolid 600 mg 12-hourly

Daptomycin 4–6 mg/kg 24-hourly

Ceftaroline 600 mg 12-hourly

Dalbavancin 1000 mg once followed by 500 mg after 1 week or 1500 mg one dose

Tedizolid 200 mg 24-hourly

Televancin 10 mg/kg 24-hourly